## Background: Fadrozole hydrochloride (cgs 16949a) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. circulating estradiol, estrone, and
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Synthesis of 14C-labelled CGS 16949A (Fadrozole HCl), a potent aromatase inhibitor
โ Scribed by Bohdan Markus; Alban J. Allentoff; Mahesh Desai; Naba K. Chaudhuri; Timothy Duelfer
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 318 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
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CGS 19755 is a selective NMDA (N-methyl-D-aspartate) antagonist presently under development as a neuronal protecting agent after stroke and head trauma. It was synthesized with 1%-labelling in the carboxylic acid side chain via the synthetic route displayed in Scheme 1. Key steps in the synthesis in