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Factors influencing nortriptyline steady-state kinetics: Plasma and saliva levels

✍ Scribed by Kragh-Sørensen, Per; Larsen, Niels-Erik

Book ID
109842942
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
339 KB
Volume
28
Category
Article
ISSN
0009-9236

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✍ J. E. Burch 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 506 KB

Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a crossover design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 time