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Factor V Leiden-dependent APC resistance: Improved sensitivity and specificity of the APC resistance test by plasma dilution in factor V-depleted plasma

✍ Scribed by Michèle Gouault-Heilmann; Catherine Leroy-Matheron


Book ID
116087142
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
221 KB
Volume
82
Category
Article
ISSN
0049-3848

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A single point mutation of the factor V (FV) gene, leading to the substitution Arg506Gln in the FV molecule (FV-Leiden) and hence resistance to its breakdown by activated protein C (APC), is the most prevalent risk factor for venous thrombosis in the Caucasians. A ratio determined by activated parti