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Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation

โœ Scribed by J. M. BRUGGE; P. SIMIONI; F. BERNARDI; D. TORMENE; B. LUNGHI; G. TANS; A. PAGNAN; J. ROSING; E. CASTOLDI


Book ID
109149254
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
228 KB
Volume
3
Category
Article
ISSN
1538-7933

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Prevalence of the factor V-Leiden mutati
โœ Gregg, Jeff P.; Yamane, Akemi J.; Grody, Wayne W. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 8 KB ๐Ÿ‘ 2 views

Resistance to activated protein C (APC) is the most common risk factor for venous thromboembolism, a major cause of morbidity and mortality with an incidence of about 1/1,000 per year. The Arg 506 to Gln mutation in exon 10 of the coagulation factor V gene (factor V-Leiden) has been found to be resp