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Facilitation of stimulatory effect of chlordiazepoxide-amphetamine combination by subacute administration of chlordiazepoxide in mice

✍ Scribed by Mario Sansone; Paolo Renzi; Jerzy Vetulani

Publisher: Springer
Year: 1986
Tongue: English
Weight: 317 KB
Volume: 89
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00175188

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✦ Synopsis

Spontaneous locomotor activity was tested in CD-1 mice receiving subacutely (for 4 days) chlordiazepoxide (10 mg/kg) and then treated with d-amphetamine (0.5 or 1 mg/kg) and various doses of chlordiazepoxide (2.5, 5 or 10 mg/kg) separately or in combination. Chlordiazepoxide pretreatment enhanced the stimulatory effect of the chlordiazepoxide-amphetamine combination.

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Effects of repeated administration of chlordiazepoxide on spontaneous locomotor activity in mice

✍ Mario Sansone 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 191 KB

Spontaneous locomotor activity has been studied in mice treated with single or repeated doses (five daily injections) of chlordiazepoxide. The repeated administration enhanced the stimulatory action of the lower doses of the drug, while the depressant effect of the higher doses was reduced.