Effects of repeated administration of chlordiazepoxide on spontaneous locomotor activity in mice
β Scribed by Mario Sansone
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 191 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
Spontaneous locomotor activity has been studied in mice treated with single or repeated doses (five daily injections) of chlordiazepoxide. The repeated administration enhanced the stimulatory action of the lower doses of the drug, while the depressant effect of the higher doses was reduced.
π SIMILAR VOLUMES
Spontaneous locomotor activity was tested in CD-1 mice receiving subacutely (for 4 days) chlordiazepoxide (10 mg/kg) and then treated with d-amphetamine (0.5 or 1 mg/kg) and various doses of chlordiazepoxide (2.5, 5 or 10 mg/kg) separately or in combination. Chlordiazepoxide pretreatment enhanced th
Neonatal rats treated on day 3 of life with 50 or 100 ~tg 5,7-dihydroxytryptamine exhibited long-lasting selective depletions of serotonin (5-HT). The 5-HT depletions produced a shift in the peak in locomotor activity from its normal occurrence at 15 days of age to later days of age. The observation