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Facilitation of Peptide Synthesis by the Use of 4-Picolyl Esters: Synthesis of Val5–Angiotensin II

✍ Scribed by GARNER, R.; YOUNG, G. T.

Book ID
109667054
Publisher
Nature Publishing Group
Year
1969
Tongue
English
Weight
189 KB
Volume
222
Category
Article
ISSN
0028-0836

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## Abstract The synthesis of [Sar^1^, Val^5^, (4′‐azido‐3′,5′‐ditritio)Phe^8^] angiotensin II from a iodinated precursor peptide is described. The principal problems of this synthesis and their resolution are discussed: (i) The β‐induced autophotolysis of the highly tritiated (73 Ci/mmol) and photo