Electronic and chemical marker methods provide the first reliable measurements of drug exposure in ambulatory trials. These data contradict the usual claim in published drug trials of '90% of patients having been satisfactorily compliant with the protocol-specified dosing regimen. Such exaggerated c
Facilitated analysis of data on drug regimen compliance
โ Scribed by Erik De Klerk; Sjef Van Der Linden; Desiree Van Der Heijde; John Urquhart
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 188 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
โฆ Synopsis
Drug actions depend on dose and intervals between doses, in ways that are drug-specific and sometimes complex, complicating the use of drug dosing histories as an explanatory variable in the analysis of clinical trials. We describe a spread-sheet method for conveniently displaying patients' drug dosing histories, to facilitate identification of dosing correlates of clinically important events.
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