✦ LIBER ✦

Facile Synthesis, Single-Crystal Structure, and Biological Evaluation of Novel Pyrazolo[5,1-d][1,2,5]triazepin-4-ones

✍ Scribed by Liang-Wen Zheng; Hong-Zhuan Xuan; Ying-Rui Liu; Bao-Xiang Zhao; Jin-Ting Liu; Jun-Ying Miao

Publisher: John Wiley and Sons
Year: 2012
Tongue: German
Weight: 380 KB
Volume: 95
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201100249

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✦ Synopsis

A facile ring-enlargement reaction of 2,6-diphenyl-4H-pyrazolo [5,1-c][1,4]oxazin-4-one is described, generating the pyrazolo [5,1-d][1,2,5]triazepin-4-ones in good yields. Structures of the prepared compounds were determined on the basis of IR, 1 H-and 13 C-NMR, and HR-MS data. Moreover, the molecular structure was confirmed by the X-ray crystal-structure analysis of one compound that was prone to crystallization. Preliminary biological evaluation showed that the compounds 2e -2h promote the viability and inhibit the apoptosis of vascular endothelial cells at low concentration.

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