Facile synthesis of α-iodo carbonyl compounds and α-iodo dimethyl ketals using molecular iodine and trimethylorthoformate

✍ Scribed by J.S. Yadav; G. Kondaji; M. Shiva Ram Reddy; P. Srihari

• Book ID: 104095287
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 131 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.03.151

✦ Synopsis

A novel and direct method for the synthesis of a-iodo ketones and a-iodo dimethyl ketals from acetophenones using iodine and trimethylorthoformate under neutral conditions is described herein.