β Scribed by Keuper, Ralf ;Risch, Nikolaus
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The preparation of polycyclic heterocycles with one or more nitrogen atoms and different binding angles by a domino reaction is described. These compounds (4β6, 8aβb) are formed by the reaction of Ξ²βamino ketone hydrochlorides 1 or 2 (Mannich bases) with ketones 3. Especially the synthesis of the terpyridines 8a and 8b in a double domino reaction is very useful (yield 70 and 59%) and opens a route to torands.
π SIMILAR VOLUMES
## Abstract Cyclocondensation of cyanoacetamide and cyanothioacetamide with sodium salt of 3βhydroxyβ1β(pyridinβ3βyl)propβ2βenβ1βone gave 6βoxoβ[2,3β²]bipyridine **5a** and 6βthioxoβ[2,3β²]bipyridine **5b** derivatives, respectively. Compound **5b** upon treatment with different methylenes **8** gave
## Abstract For Abstract see ChemInform Abstract in Full Text.
A facile, solvent free, ecofriendly approach for the synthesis of 2-amino-3(ethylcarboxy)-4,6-disubstituted pyridine 4 and pyrazolo [3,4-b]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it comp