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A facile synthesis of substituted pyridines and pyrazolo[3,4-b]pyridines

✍ Scribed by M. Kidwai; R. Thakur; S. Saxena

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
57 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

A facile, solvent free, ecofriendly approach for the synthesis of 2-amino-3(ethylcarboxy)-4,6-disubstituted pyridine 4 and pyrazolo [3,4-b]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure. The observed reaction rate enhancement and high yield of products are due to the neat reaction conditions coupled with microwaves (MWs).

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## Abstract Cyclocondensation of cyanoacetamide and cyanothioacetamide with sodium salt of 3‐hydroxy‐1‐(pyridin‐3‐yl)prop‐2‐en‐1‐one gave 6‐oxo‐[2,3β€²]bipyridine **5a** and 6‐thioxo‐[2,3β€²]bipyridine **5b** derivatives, respectively. Compound **5b** upon treatment with different methylenes **8** gave