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Facile synthesis of platelet-activating factor and racemic analogs containing unsaturation in the sn-1-alkyl chain

โœ Scribed by Surles, Jefferson R.; Wykle, Robert L.; O'Flaherty, Joseph T.; Salzer, William L.; Thomas, Michael J.; Snyder, Fred; Piantadosi, Claude


Book ID
115451947
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
931 KB
Volume
28
Category
Article
ISSN
0022-2623

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On the synthesis of platelet-activating
โœ V.V Chupin; O.V Ostapenko; V.N Klykov; M.V Anikin; G.A Serebrennikova ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 537 KB

It has been shown that platelet-activating factor (PAF) specimens prepared via acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso-PF) with acetic anhydride are heterogeneous. The contaminated compound was isolated and identified to be the structural isomer of PAF, 1-alkyl-3-acetyl-sn-glycero-2

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The multistep synthesis of a platelet activating factor (PAF) analog having a reactive aldehyde group at the ~-end of the sn-I position is described. A novel ozonolysis of a double bond was employed to generate the aldehyde group in high yield under mild conditions. The aldehyde group was generated