Facile synthesis of peptide–porphyrin conjugates: Towards artificial catalase
✍ Scribed by Naoki Umezawa; Nobuyoshi Matsumoto; Shinsuke Iwama; Nobuki Kato; Tsunehiko Higuchi
- Book ID
- 108072896
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 880 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0968-0896
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The development of NO donors with site-specific and time-controlled properties is of great interest. We have designed a novel prodrug class as possible agents against metastatic prostate cancer by coupling a diazeniumdiolate to the terminal carboxyl groups of amino acids or peptides, such as Ser-Ser
## Abstract Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or D
The design and synthesis of a novel peptide strapped porphyrin is described. CD spectroscopy and 1H NMR are supportive of the design.