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Facile synthesis of cyclic peptides containing di-, tri-, tetra-, and pentasulfides

✍ Scribed by Daniel A. Erlanson; James A. Wells


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
245 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


We describe an efficient method for constructing cyclic polysulfide-containing peptides. The synthesis uses commercially available bis-(tetrabutylammonium) hexasulfide (BTH) and can be performed in aqueous solution. Preliminary structural analyses indicate that varying the number of sulfur atoms affects the conformation of the peptide in solution.


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