Facile synthesis of cyclic peptides containing di-, tri-, tetra-, and pentasulfides
✍ Scribed by Daniel A. Erlanson; James A. Wells
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 245 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We describe an efficient method for constructing cyclic polysulfide-containing peptides. The synthesis uses commercially available bis-(tetrabutylammonium) hexasulfide (BTH) and can be performed in aqueous solution. Preliminary structural analyses indicate that varying the number of sulfur atoms affects the conformation of the peptide in solution.
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