A facile method for the direct synthesis of lanthionine containing cyclic peptides
โ Scribed by Amit K. Galande; Arno F. Spatola
- Publisher
- Springer Netherlands
- Year
- 2001
- Tongue
- English
- Weight
- 405 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1573-3149
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A general method is described for the synthesis of thioether cychc peptides. The thioether linkage of cyclic peptides was formed in moderate to high yield through an intramolecular substitution of the chloro group of [3-chloroalanine with the thiol group of cysteine~ The peptides containing [3chloro
A selective and efficient method for disulfide bond formation in pepti\_' \_de~\_ \_ u "tdizin8 cartxm ~de in dichlommethane in the presence of tetrabutylammonium fluoride (TBAF) is described. The reactloa gt, ceeded rapidly and no side reaction was observed with nuclcophific amino acids such as Met