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Facile synthesis of chiral 1,2-chlorohydrins via the ring-opening of meso-epoxides catalyzed by chiral phosphine oxides

โœ Scribed by Kotani, Shunsuke; Furusho, Haruka; Sugiura, Masaharu; Nakajima, Makoto


Book ID
120057812
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
890 KB
Volume
69
Category
Article
ISSN
0040-4020

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Enantioselective ring opening of meso-ep
โœ Makoto Nakajima; Makoto Saito; Michinao Uemura; Shunichi Hashimoto ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 74 KB

An enantioselective ring opening of meso-epoxides with tetrachlorosilane in the presence of diisopropylethylamine exploiting chiral bipyridine N,N%-dioxides as catalysts affords the corresponding chlorohydrins in high enantioselectivities of up to 90% ee.