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Facile synthesis of 5′-(N-acyl sulfonamide) derivatized nucleosides

✍ Scribed by David C Johnson II; Theodore S Widlanski

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
86 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The acylation of several primary sulfonamides with N 6 -benzoyl-2%,3%-isopropylidene-5%-carboxylic acid-5%deoxyadenosine (1) is described. Literature methods for the construction of the N-acyl sulfonamide functionality proved ineffective for synthesizing 5%-N-acyl sulfonamide derivatives of 1. The combination of DCC/DMAP provided the mild conditions necessary to effect coupling of the protected nucleoside acid with various primary sulfonamides in good to high yield.

📜 SIMILAR VOLUMES

ChemInform Abstract: Facile Synthesis of
ChemInform Abstract: Facile Synthesis of 5′-(N-Acyl sulfonamide) Derivatized Nucleosides.
✍ David C. Johnson II; Theodore S. Widlanski 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Multiple Routes for
ChemInform Abstract: Multiple Routes for the Synthesis of N-Acyl Sulfonamide-Bridged Nucleosides.
✍ David C. Johnson II; Theodore S. Widlanski 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v