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Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine α ketoglutarate dioxygenase (TauD)

✍ Scribed by Kevin P. McCusker; Judith P. Klinman


Book ID
108285313
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
189 KB
Volume
50
Category
Article
ISSN
0040-4039

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Valuable new synthetic intermediates, 7-chloromethyl-1H-indole-2-carboxylates (3a-d), were prepared by the facile elimination of sulfur dioxide under the influence of thionyl chloride from 2-ethoxycarbonyl-1H-indole-7-methanesulfonic acids (1a-d), easily accessible by Fischer-type indolisation. The