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Facile synthesis of 1-aminoisoquinolines via the tandem reactions of 2-alkynylbenzaldoximes with isothiocyanates

✍ Scribed by Wenhai Li; Yue Wang; Tao Lu


Book ID
116909572
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
331 KB
Volume
68
Category
Article
ISSN
0040-4020

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Facile Synthesis of 1-(Isoquinolin-1-yl)
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## Abstract 2‐Alkynylbenzaldoximes react with carbodiimides under mild conditions and silver triflate catalysis in DMF, leading to a diverse range of 1‐(isoquinolin‐1‐yl)ureas in good to excellent yields. This transformation involves tandem 6‐__endo__ cyclization, [3+2] cycloaddition, and subsequen