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Facile Synthesis and Evaluation of Antitumor and Antiviral Activities of [1,2,5]Thiadiazolo[3,4-d]pyrimidines (8-Thiapurines) and 4-β-D-Ribofuranosyl[1,2,5]thiadiazolo[3,4-d]pyrimidines.

✍ Scribed by Tomohisa Nagamatsu; Rafiqul Islam; Noriyuki Ashida


Publisher
John Wiley and Sons
Year
2007
Weight
29 KB
Volume
38
Category
Article
ISSN
0931-7597

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Abstract

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ChemInform Abstract: Synthesis of 1,2,3-
✍ E. V. TARASOV; YU. YU. MORZHERIN; N. N. VOLKOVA; V. A. BAKULEV 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Synthesis of 1,2,3-Thiadiazolo (5,4-d)pyrimidines. -Condensation of 5-aminothiadiazole-4-carboxamides (I) or (IV) with orthoesters provides the target thiadiazolopyrimidines in moderate to good yield. Attempts to synthesize this heterocyclic system by three-component condensation of readily availab