Vitamin D3 active metabolites 24R,25-(OH)2-D3, 24S,25-(OH)2-D3, and 1 alpha, 24R,25-(OH)3-D3 were synthesized by a convergent and stereoselective approach. In the synthetic route, the stereogenic center at C-24 was generated through ultrasonically induced aqueous conjugate addition of iodide 6 to Se
β¦ LIBER β¦
Facile, stereoselective synthesis of (24R)-24,25-dihydroxyvitamin D3 using D-glyceric acid as a chiral synthon
β Scribed by Hiroaki Takayama; Masayuki Ohmori; Sachiko Yamada
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 149 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
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Vitamin D3 is known to undergo functional metabolism first in the liver, resulting in 25, hydroxy vitamin D3 which is transformed latter in the kidney to la,25-and 24(R),25\_dihydroxy vitamin D 3, both hormonally active in calciumhomeostasis.' The activity of D2 in mammals