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Facile Preparation of a New BINAP-Based Building Block, 5,5‘-DiiodoBINAP, and Its Synthetic Application

✍ Scribed by Shimada, Toyoshi; Suda, Masahiko; Nagano, Toyohiro; Kakiuchi, Kiyomi


Book ID
127088035
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
97 KB
Volume
70
Category
Article
ISSN
0022-3263

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Optically active trans-4-(tert-butyldimethylsiloxymethyl)-5-(tert-butyldimethylsiloxy)-2-cyclohexenone (2) has been synthesized in 25% overall yield starting from easily available 1,4-bis(benzyloxy)-2,3-epoxy butane (3). The enone 2 reacts with excellent stereoselectivity with RCu(CN)Li thus working