The Ugi four-component condensation (4-CC) between amines 4, aromatic aldehydes 5, chloroacetic acid 6 and isocyanides 7 afforded the expected 4-CC adducts 8 which were cyclised to the title compounds 9 upon treatment with ethanolic KOH under ultrasonication.
β¦ LIBER β¦
Facile one-step synthesis of 2,5-diketopiperazines
β Scribed by Sun, Xianyu; Rai, Rachita; MacKerell, Alexander D.; Faden, Alan I.; Xue, Fengtian
- Book ID
- 123549545
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- French
- Weight
- 730 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4039
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