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Facile One-Pot Three-Component Synthesis of Functionalized Pyridylfuran-2-amines

✍ Scribed by Mehdi Adib; Mohammad Hosein Sayahi; Somayeh Aali Koloogani; Peiman Mirzaei

Publisher
John Wiley and Sons
Year
2006
Tongue
German
Weight
65 KB
Volume
89
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The reactive 1 : 1 zwitterionic intermediates generated in situ from the reaction between a series of isocyanides and diaroylacetylenes were trapped by pyridine carbaldehydes to yield highly functionalized 5‐pyridylfuran‐2‐amines in good yields (82–93%).

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✍ Kurosh Rad-Moghadam; Laleh Samavi 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 69 KB

## Abstract magnified image A facile and rapid synthesis of the title compounds via one‐pot reaction of 2‐aminobenzonitrile, orthoesters and ammonium acetate under solvent‐free and microwave condition is described.