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Facile coupling of 2-(1-ethylthioethenyl)pyrroles with amines: A route to 2-(1-aminoethenyl)pyrroles and 1-amino-3-iminopyrrolizines

✍ Scribed by Boris A. Trofimov; Lyubov' N. Sobenina; Al'bina I. Mikhaleva; Ol'Ga V. Petrova; Vladislav N. Drichkov; Igor A. Ushakov; Ol'Ga A. Tarasova; Darya-Suren D. Toryashinova; Yuriy Yu. Rusakov; Leonid B. Krivdin

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
645 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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2‐(2‐Cyano‐1‐ethylthioethenyl)pyrroles are readily coupled (50–55°) with primary and secondary amines at the position 1 of the ethenyl moiety to eliminate ethanethiol and afford 2‐(1‐amino‐2‐cyanoethenyl)pyrroles and/or their cyclic isomers ‐ functionalized 1‐amino‐3‐iminopyrrolizines in good to high yields.

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