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Facile conversion of racemic ibuprofen to (S)-ibuprofen

โœ Scribed by David Chavez-Flores; James M. Salvador


Book ID
113929655
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
326 KB
Volume
23
Category
Article
ISSN
0957-4166

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๐Ÿ“œ SIMILAR VOLUMES


S-Ibuprofen versus ibuprofen-racemate
โœ K. P. Stock; G. Geisslinger; D. Loew; W. S. Beck; G. L. Bach; K. Brune ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 349 KB

Ibuprofen (ibu) is a racemic 2-arylpropionic acid non-steroidal anti-inflammatory drug whose activity is due mainly to the S-enantiomer. So far only the racemic compound is in clinical use. A double-blind randomized trial was carried out for a 2-week period in 50 patients with classical rheumatoid a

S(+) versus racemic ibuprofen
โœ Klein, G.; Neff, H.; Kullich, W.; Phleps, W.; Kollenz, ChJ. ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› The Lancet ๐ŸŒ English โš– 161 KB
Topical administration of racemic ibupro
โœ J. S. Millership; P. S. Collier ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 125 KB

In vitro experiments to investigate possible stereoselective aspects of the topical administration of ibuprofen have been conducted. Incubation of ibuprofen with rat skin homogenates in the presence of coenzyme A, ATP, and magnesium provided no evidence for the formation of ibuprofenyl coenzyme A (t