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Facile and convenient strategy towards synthesis of 4-substituted 2-aminothiazolo[4,5-d]pyridazinones

✍ Scribed by Amol A. Thorave; Pinkal N. Prajapati; Jignesh P. Pethani; Krunal C. Kothari; Mukul R. Jain; Pankaj R. Patel; Rajendra K. Kharul

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 802 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.07.105

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✦ Synopsis

Convenient synthesis of 4-substituted 2-aminothiazolo [4,5-d]pyridazinones has been achieved in 12 steps with overall yield of 19% by employing Grignard reaction as the key step. The route utilizes well established thiazole ring formation followed by Grignard reaction to introduce substitution at 4-position effectively. In addition to the use of inexpensive chemicals, the present route first time gave access to the 4-substituted 2-aminothiazolo [4,5-d]pyridazinones with free amino group at C-2 position.

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