Fabrication and characterization of hydrophilic electrospun membranes made from the block copolymer of poly(ethylene glycol-co-lactide)

✍ Scribed by De-Juan Yang; Li-Fang Zhang; Liang Xu; Cheng-Dong Xiong; Jing Ding; Yu-Zhong Wang

• Book ID: 102873315
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 695 KB
• Volume: 82A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.31099

✦ Synopsis

Abstract

To improve the hydrophilicity, pliability, and egradability of some biodegradable polymers such as polylactide (PLA), a triblock copolymer, and poly(ethylene glycol‐co‐lactide) (PELA) has been electrospun into fibrous membranes in the fiber sizes of 7.5 μm to 250 nm. The relationship between electrospinning parameters (such as voltage, concentration, and feeding rate) and the fiber diameters has been investigated. The characterizations for the structure and morphology of electrospun membranes were carried out using differential scanning calorimetry (DSC), ^1^H NMR, and scanning electron microscopy (SEM). The hydrophilicity of the membrane was determined by contact angle measurements in bidistilled water, and it was shown that the hydrophilicity of the copolymer could be adjusted by the content of the poly (ethylene glycol) (PEG) segment in the copolymer. The results of in vitro degradation study showed that the submicrostructure of the fibrous membrane and the incorporation of hydrophilic PEG into PLA block could accelerate the degradation of the membrane in regards to the changes of inherent viscosity, tensile strength, and weight loss. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007