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FAB and tandem mass spectrometry of synthetic neuropeptides and their 2H-labelled analogues

✍ Scribed by S. V. Waghmare; R. H. Fokkens; N. M. M. Nibbering; F. M. Kaspersen

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
352 KB
Volume
18
Category
Article
ISSN
1076-5174

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✦ Synopsis

Fast atom bombardment (FAB) combined with tandem mass spectrometry has been used to verify the amino acid sequence in Org 2766 IH-Met(0,)-Glu-His-Phe-D-Lys-PheOH) and its deuterated analogues. It is shown that FAB mass spectrometry in addition to the [M + HJ' ion yields dominantly N-terminal sequence ions and some C-terminal sequence ions. These results together permit determination of the amount of deuterium incorporated and the position of the deuterated amino acids in the peptide.

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