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F-box protein Skp2: a novel transcriptional target of E2F

✍ Scribed by Zhang, L; Wang, C


Book ID
110070310
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
498 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract The F‐box protein Skp2 positively regulates the G1‐S transition by promoting degradation of the cyclin‐dependent kinase inhibitor p27^kip1^ (p27). Recent evidence has suggested an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed imm