## Abstract The Fβbox protein Skp2 positively regulates the G1βS transition by promoting degradation of the cyclinβdependent kinase inhibitor p27^kip1^ (p27). Recent evidence has suggested an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed imm
Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer
β Scribed by Radke, Susanne; Pirkmaier, Andreja; Germain, Doris
- Book ID
- 110069389
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 543 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit
## Abstract The expression of Skp2, the ubiquitin ligase subunit that targets p27^Kip1^ for degradation, is commonly overexpressed in human cancers. p27^Kip1^ is a negative regulator of the cell cycle that plays an important role in tumor suppression. Loss of p27^Kip1^ secondary to enhanced ubiquit