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Extrathymic mechanisms of T cell tolerance: Lessons from autoimmune gastritis

✍ Scribed by Thea V. Hogan; Desmond K.Y. Ang; Paul A. Gleeson; Ian R. van Driel

Book ID
116614144
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
301 KB
Volume
31
Category
Article
ISSN
0896-8411

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Murine autoimmune gastritis is one of the most well-defined organ-specific autoimmune diseases. CD4(+) T cells, which mediate the disease, recognize the highly abundant gastric H(+)/K(+) ATPase heterodimer. The H(+)/K(+) ATPase alpha subunit is also expressed in the thymus, in an aire-independent ma