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Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

✍ Scribed by Pifl, Christian; Bertel, Oswald; Schingnitz, Günther; Hornykiewicz, Oleh


Book ID
122844599
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
708 KB
Volume
17
Category
Article
ISSN
0197-0186

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP