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Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy

✍ Scribed by Leonardo Bonilha; Jonathan C. Edwards; Stephen L. Kinsman; Paul S. Morgan; Julius Fridriksson; Chris Rorden; Zoran Rumboldt; Donna R. Roberts; Mark A. Eckert; Jonathan J. Halford

Book ID
109111647
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
814 KB
Volume
51
Category
Article
ISSN
0013-9580

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## Abstract Memory impairment observed in patients with medial temporal lobe epilepsy (MTLE) is classically attributed to hippocampal atrophy. The contribution of extrahippocampal structures in shaping memory impairment in patients with MTLE is not yet completely understood, even though atrophy in

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The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {'\*F}fluorodeoxyglucose positron emission tomography and neur