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Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

โœ Scribed by Dr. Thomas R. Henry; Thomas L. Babb; Jerome Engel Jr; John C. Mazziotta; Michael E. Phelps; Paul H. Crandall

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
295 KB
Volume
36
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {'*F}fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.

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Whether temporal lobe epilepsy is the result of an isolated, early injury or whether there is ongoing neuronal dysfunction or loss due to seizures is often debated. We attempt to address this issue by using magnetic resonance techniques. Proton magnetic resonance spectroscopic imaging can detect and