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Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer

✍ Scribed by Hajime Nakamura; Hiroshi Masutani; Junji Yodoi

Book ID
113900286
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
850 KB
Volume
16
Category
Article
ISSN
1044-579X

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## Abstract Thioredoxin (TRX) is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system. TRX protects cells from stress‐induced damage through antioxidative, antiapoptotic, and anti‐inflammatory effect. In animal models, thioace