Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration
โ Scribed by Loren H. Parsons; Geroge F. Koob; Friedbert Weiss
- Book ID
- 116104194
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 364 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0166-4328
No coin nor oath required. For personal study only.
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Rats were treated for 10 days with cocaine (20 mgkg, i.p.1 followed by either 1 or 10 days of abstinence. On the test day a microdialysis method was performed in which dopamine (DA) was added to the perfusate at concentrations above and below the expected extracellular concentration (0,2.5, 5, and 1
Alterations in the density of GABA and glutamate immunolabeling within nerve terminals in the shell region of the nucleus accumbens were assessed in rats withdrawn from intravenous cocaine exposure. Four groups of rats were used: one group self-administered cocaine (0.42 mg/kg/infusion) in daily 3-h