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Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration

โœ Scribed by Friedbert Weiss; Athina Markou; Marge T. Lorang; George F. Koob


Book ID
115803284
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
487 KB
Volume
593
Category
Article
ISSN
0006-8993

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Basal extracellular dopamine is decrease
โœ L. H. Parsons; A. D. Smith; Dr. J. B. Justice Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 743 KB

Rats were treated for 10 days with cocaine (20 mgkg, i.p.1 followed by either 1 or 10 days of abstinence. On the test day a microdialysis method was performed in which dopamine (DA) was added to the perfusate at concentrations above and below the expected extracellular concentration (0,2.5, 5, and 1