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Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity

✍ Scribed by S Klawitter; L P Hofmann; J Pfeilschifter; A Huwiler


Book ID
110009371
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
170 KB
Volume
150
Category
Article
ISSN
0007-1188

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HeLa cell spreading on a gelatin substrate requires the activation of protein kinase C (PKC), which occurs as a result of cell-attachment-induced activation of phospholipase A2 (PLA2) to produce arachidonic acid (AA) and metabolism of AA by lipoxyginase (LOX). The present study examines how PKC acti