Extracellular matrix formation by osteoblasts from patients with osteogenesis imperfecta
โ Scribed by Neal S. Fedarko; Martin Moerike; Rolf Brenner; Pamela Gehron Robey; Ulrich Vetter
- Book ID
- 112118955
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2009
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0884-0431
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Osteopenia due to deficient extracellular matrix synthesis is a hallmark of osteogenesis imperfecta (OI). Previous studies carried out within 72 h of osteoblast subculture, at an early stage of matrix synthesis, indicated that for osteoblasts derived from human OI patients the total amo
## Abstract We studied the expression of osteoblastic markers in cultured cells isolated from the bone of 15 patients with different clinical forms of osteogenesis imperfecta (OI) and of seven fetal and postnatal controls. Cultured bone cells of ten OI patients produced abnormal collagen type I. Si