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Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells

✍ Scribed by Fabrice Journé, Naïma Kheddoumi, Carole Chaboteaux…


Book ID
120699244
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
741 KB
Volume
10
Category
Article
ISSN
1465-5411

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Addition of ATP (>0.1 mM) to cultures of human breast cancer T47D cells resulted in an inhibition of cell proliferation. The inhibition was found to be specific for ATP, and dependent on its concentration. Growth inhibition continued for at least three days, although ATP and its hydrolysis products