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Extracellular Activities of Human Granzymes: I. Granzyme A Induces IL6 and IL8 Production in Fibroblast and Epithelial Cell Lines

โœ Scribed by Laurie E. Sower; Gary R. Klimpel; William Hanna; Christopher J. Froelich


Book ID
112239586
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
88 KB
Volume
171
Category
Article
ISSN
0008-8749

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## Abstract Human neutrophil peptides (HNP) kill microorganisms but also modulate immune responses through upregulation of the chemokine ILโ€8 by activation of the nucleotide P2Y~6~ receptor. However, the intracellular signaling mechanisms remain yet to be determined. Human lung epithelial cells (A5