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Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells

✍ Scribed by Imai, Haruka; Fujita, Tsuyoshi; Kajiya, Mikihito; Ouhara, Kazuhisa; Miyagawa, Tsuyoshi; Matsuda, Shinji; Shiba, Hideki; Kurihara, Hidemi

Book ID: 125825758
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 858 KB
Volume: 290
Category: Article
ISSN: 0008-8749
DOI: 10.1016/j.cellimm.2014.07.001

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## Abstract Human neutrophil peptides (HNP) kill microorganisms but also modulate immune responses through upregulation of the chemokine IL‐8 by activation of the nucleotide P2Y~6~ receptor. However, the intracellular signaling mechanisms remain yet to be determined. Human lung epithelial cells (A5