absolutely unfailing way. This problem is largely ignored in traditional studies on eukaryotic DNA replication. ## Summary A hypothesis for the control of eukaryotic DNA replication at the chromosomal level is proposed. The specific regulatory problem arises from the subdivision of the genome int
Extra-chromosomal elements and the evolution of cellular DNA replication machineries
β Scribed by McGeoch, Adam T.; Bell, Stephen D.
- Book ID
- 109958982
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 403 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm2426
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In eukaryotic organisms, genes involved in DNA replication are often subject to some form of cell cycle control. In the yeast Saccharomyces cerevisiae, most of the DNA replication genes that have been characterized to date are regulated at the transcriptional level during G1 to S phase transition. A
## Abstract We previously characterized a functional origin of DNA replication at the transcriptional promoter of the human hypoxanthineβguanine phosphoribosyltransferase (__HPRT__) gene (Cohen et al. [2002] J. Cell. Biochem. 85:346β356). This origin was mapped using a quantitative PCR assay to eva