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Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status

✍ Scribed by T. Tanaka; A. Kurose; X. Huang; F. Traganos; W. Dai; Z. Darzynkiewicz


Book ID
108677713
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
206 KB
Volume
39
Category
Article
ISSN
0960-7722

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D