Extensive parent-of-origin genetic effects on fetal growth
β Scribed by Ronald M Adkins; Julia Krushkal; Grant Somes; John Fain; John Morrison; Chad Klauser; Everett F Magann
- Book ID
- 114999053
- Publisher
- BioMed Central
- Year
- 2009
- Tongue
- English
- Weight
- 165 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1471-2105
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## Abstract Genomic imprinting refers to a parentβofβorigin specific effect on gene expression. At least 1% of genes in the human genome are modulated in this manner. We sought evidence for genomic imprinting in colorectal cancer by studying the ages at diagnosis in the offspring of 2,061 parentβch
Many complex genetic effects, including epigenetic effects, may be expected to operate via mechanisms in the inter-uterine environment. A popular design for the investigation of such effects, including effects of parent-of-origin (imprinting), maternal genotype, and maternal-fetal genotype interacti