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Extension of the “Ring Switch” Approach to Glutamate Antagonists to δ-Lactam Urethanes.

✍ Scribed by Diane Coe; Martin Drysdale; Oliver Philps; Robert West; Douglas W. Young


Book ID
101939421
Publisher
John Wiley and Sons
Year
2003
Weight
150 KB
Volume
34
Category
Article
ISSN
0931-7597

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Extension of ring switching strategy to
✍ Andrew Dinsmore; Paul M Doyle; Peter B Hitchcock; Douglas W Young 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 113 KB

2-(Pyrimidin-2,4-dione-5-ylmethyl)-(2S)-glycine 8 has been prepared by treatment of the pyroglutamate urea 12 with mild base, followed by deprotection in a modification of our ring switching approach to the synthesis of glutamate antagonists. The product is an isomer of the natural product willardii