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Extension of the ???ring switch??? approach to glutamate antagonists to ??-lactam urethanes

✍ Scribed by Coe, Diane; Drysdale, Martin; Philps, Oliver; West, Robert; Young, Douglas W.


Book ID
121376787
Publisher
Royal Society of Chemistry
Year
2002
Weight
297 KB
Volume
22
Category
Article
ISSN
1472-7781

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Extension of ring switching strategy to
✍ Andrew Dinsmore; Paul M Doyle; Peter B Hitchcock; Douglas W Young πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 113 KB

2-(Pyrimidin-2,4-dione-5-ylmethyl)-(2S)-glycine 8 has been prepared by treatment of the pyroglutamate urea 12 with mild base, followed by deprotection in a modification of our ring switching approach to the synthesis of glutamate antagonists. The product is an isomer of the natural product willardii