Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance
β Scribed by Robert P. Perrillo; Hie-Won Hann; Eugene Schiff; David Mutimer; Bernard Willems; Nancy Leung; William M. Lee; Susan Dixon; Mary Woessner; Carol L. Brosgart; Lynn D. Condreay; Stephen D. Gardner
- Book ID
- 107593919
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 309 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1936-0533
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Lamivudine treatment in patients with chronic hepatitis B virus (HBV) infection may improve clinical state and suppress viral replication before liver transplantation. Emergence of lamivudine-resistant YMDD mutant is common. We report the results of liver transplantation in 16 patients with pretrans
Although adefovir dipivoxil (ADV) has a unique profile of delayed and infrequent resistance in treatment-naΓ―ve chronic hepatitis B patients, the association of ADV resistance with previous lamivudine (LAM) resistance is not well understood. We compared the emergence of the ADV-resistant mutations rt
## Abstract Factors influencing the therapeutic efficacy of adefovir dipivoxil added to continuing lamivudine have not been elucidated in lamivudineβresistant patients with type B chronic hepatitis. The viral mutations influencing the efficacy of treatment with adefovir dipivoxil were investigated